Centos & redhat persistent static routes
On redhat centos
For each device, (say eth0) create the file: /etc/sysconfig/network-scripts/route-eth0
And the contents should be something like:
10.0.1.0/24 via 192.168.2.4 dev eth0
10.0.4.0/24 via 192.168.2.2 dev eth0